Natural Compounds to Counteract Testosterone Depletion in Aging

Natural Compounds and Aging: Between Autophagy and Inflammasome

Aging, a natural physiological process, is characterized by a progressive loss of physiological integrity. Loss of cellular homeostasis in the aging process results from different sources, including changes in genes, cell imbalance, and dysregulation of the host-defense systems. Innate immunity dysfunctions during aging are connected with several human pathologies, including metabolic disorders...

Bioactive compounds from natural resources against skin aging.

Skin aging involves degradation of extracellular matrix (ECM) in both the epidermal and dermal layers, it leaves visible signs on the surface of skin and the physical properties of the skin are modified. Chronological aging is due to passage of time, whereas premature aging occurred due to some environmental factors on skin produces visible signs such as irregular dryness, dark/light pigmentati...

Treating Aging with Testosterone.

Although some off-label medication use is justified, the use of testosterone for nonspecific symptoms of aging is not. Using testosterone to treat older men with decreased energy, decreased strength, low libido, erectile dysfunction, mood disorders, sleep disorders, or poor memory is inappropriate because symptoms do not correlate with testosterone levels, testosterone supplementation is unimpr...

Mulberry Leaf Extract Attenuates Oxidative Stress-Mediated Testosterone Depletion in Streptozotocin-Induced Diabetic Rats

Background: It has been proposed that oxidative stress may contribute to the development of testicular abnormalities in diabetes. Morus alba leaf extract (MAE) has hypoglycemic and antioxidant properties. We, therefore, explored the impact of the administration of MAE on steroidogenesis in diabetic rats. Methods: To address this hypothesis, we measured the serum level of glucose, insulin, and f...

Developing a Fuzzy Logic Model to Predict Asphaltene Precipitation during Natural Depletion based on Experimental Data